Bonta

基本解釋

Competing ELISA showed that recombinant ScFv could compete with antiserum to specific hind BoNTa.
競爭活性測定結(jié)果表明，重組抗毒素在體外具有良好的活性，可競爭肉毒抗毒素馬血清與毒素的特異結(jié)合。
Human ScFv against botulinum neurotoxin serotype A(BoNTa) was modified by fusing human IgG1 Fc to C terminal of ScFv. ScFv-Fc fusion protein was expressed at high level over 30% of total host cell proteins in E. coli.
以獲得的抗A型肉毒毒素單鏈抗體為模板,進行融合改構(gòu),將人IgG1的Fc片段連接到ScFv的C端,在大腸桿菌中實現(xiàn)抗體融合蛋白ScFv-Fc的表達,表達量30%25以上,蛋白以包含體形式存在,經(jīng)過體外變復(fù)性的抗體融合蛋白ScFv-Fc,進行Prote in G Sepharose柱親和層析純化,純度達90%25~95%25。
Bontaş
邦塔什
abstract ： To evaluate the effect of intraprostatic injection of botulinum toxin A (BoNTA) on prostate volume and refractory urinary retention in patients with benign prostatic enlargement.
評論：作者研究于良性攝護腺肥大患者接受攝護腺內(nèi)注射A型肉毒桿菌素，對于攝護腺體積與排尿改善的效果。