antibody affinity maturation

基本解釋

Conclusion Error-prone PCR is an effective and simple method for affinity maturation of antibodies isolated from a phage antibody library.
結(jié)論錯配PCR結(jié)合噬菌體展示技術(shù)是提高單鏈抗體親和力的一種有效且簡便的手段。
Because this method was to simulate the process of antibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.
該方法體外模擬了抗體親和力成熟的過程，使得到的抗體不但可以完全的人源化，而且可以具有較高的親和力。
The algorithm is inspired by the mechanism in which a kind of antibody can identify multi-epitope of an antigen and gradually accomplish affinity maturation in the evolutionary process.
基于免疫細胞中不同親和度抗體具有不同的變異率，最終通過不斷進化達到親和度成熟機理的啟示，設(shè)計并實現(xiàn)了一個多模態(tài)免疫優(yōu)化算法。