Anordrin

基本解釋

Anordrin has first been synthesized and developed in China in 1970’s .
雙炔失碳酯，是70年代我國自行研制的甾體避孕藥物，開始曾試用于抗早孕，隨后將它改作探親避孕藥(很多文獻(xiàn)將它歸為緊急避孕藥)。
Objective: To find anordrin analogs possessing higher bioactivity and lower side effect after reconstructing anordrin.
目的:通過改造雙炔失碳酯的化學(xué)結(jié)構(gòu),獲得活性更高、副作用更小的避孕藥。
The relative binding affinities (RBA) of four steroid hormonal drugs for estrogen receptors of uterine cytosol were detemined by competitive binding assay and shown to be in the following order: ethinyl ostradiul>estradiul>anordrin>danazol.
根據(jù)[~3H]E_2和E_R具有高度專一性及親和力的特性,應(yīng)用競(jìng)爭(zhēng)性試驗(yàn)比較了炔雌醇(EE)、雌二醇(E_2)、雙炔失碳酯(Anordrin)、丹那唑(D)與兔子宮胞液雌激素受體的相對(duì)結(jié)合親和力;
BONDED NORMAL PHASE HPLC DETERMINATION OF ANORDRIN
“抗孕-53”差向異構(gòu)體的鍵合相正相HPLC分析與熔融溫度測(cè)定
Keywords Anordrin;Analogue;Antifertility activity;
雙炔失碳酯;類似物;抗生育活性;